When tragedy strikes the Poplar family due to a severe illness, Dr. Turner's actions come under scrutiny. Timothy is uncertain whether he wants to become a GP or a surgeon. Meanwhile, Trixie is worried about the future of midwifery in Britain.

It's 1971, and a new era dawns with the Women’s Liberation movement in the UK. As the year unfolds, the team faces serious cases, including a premature birth, slavery, carbon monoxide poisoning, male breast cancer, child abuse, and lupus. 

Call the Midwife follows the nurses, midwives and nuns from Nonnatus House, who visit the expectant mothers of Poplar, providing the poorest women with the best possible care.